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In Remembrance
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Join Date: Aug 2006
Posts: 3,772
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In Remembrance
Join Date: Aug 2006
Posts: 3,772
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Dextromethorphan for dyskinesia?
I know that RLSmi and others are using low dose dex as a protection, but has anyone tried it for dyskinesias?
1: Amino Acids. 1998;14(1-3):75-82.
Blockade of glutamatergic transmission as treatment for dyskinesias and motor
fluctuations in Parkinson's disease.
Verhagen Metman L, Del Dotto P, Blanchet PJ, van den Munckhof P, Chase TN.
National Institute of Neurological Diseases and Stroke, National Institutes of
Health, Bethesda, Maryland, USA.
In animal models of Parkinson's disease (PD), glutamate antagonists diminish
levodopa (LD)-associated motor fluctuations and dyskinesias. We sought to
investigate if these preclinical observations can be extended to the human
disease, by evaluating the effects of three non-competitive NMDA antagonists
(dextrorphan, dextromethorphan and amantadine) on the motor response to LD in
patients with advanced PD. In four separate trials, adjuvant therapy with these
drugs reduced LD-induced dyskinesias and motor fluctuations. These findings
support the view that drugs acting to inhibit glutamatergic transmission at the
NMDA receptor can ameliorate LD associated motor response complications.
PMID: 9871445 [PubMed - indexed for MEDLINE]
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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