I'm not on Lyrica but on Neurontin, have been for more than 5 years now (more than 14 years with RSD). It does make me very tired and slow. I exhaust pretty easily too. They tried to put me on Lyrica instead of Neurontin, Lyrica was newer and was supposed to be better, but I didn't tolerate it at all. I had just eaten and my stomach was full. After taking the Lyrica, I felt a hunger like I've never felt before. I wanted to and could eat just about anything in sight. Of course I didn't, I had just eaten, but the hunger was intolerable. The feeling of an empty stomach can be a trigger for migraines, and so I got a massive migraine. I only took 1 Lyrica pill and was back on Neurontin the next day. Lyrica isn't the only anti convulsant out there, but I think they all pretty much make you tired and that there is an issue with weight gain in a number of them. I don't get that so much with the Neurontin. I tolerate Neurontin well. Yes, there are side-effects and they are an issue, but RSD without any pain relief is so much worse. I think finding the medication that's right for you is key, and what's right for one of us isn't necessarily right for another person.