Quote:
Originally Posted by cat265
Thanks jccgf,
I have had not your typical symptoms; extreme muscle fatigue after exerction (eg. sometimes I can barely make it up a flight of stairs, if I do I have to sit for a few moments until the strength come back into my legs) though the weird thing about this is it comes and goes I could do the same activity the next day and not have the same reaction. Iam always tired. I did have an MRI that showed multipule lesions, I never got an answer as to what casued them. Brain fog/word recall has been a big issue. I did have a low b12 but Iam takeing care of that, my last blood test was 650 (or right around there) I guess my memory (right now I can't think of my symptom, its like I go to use my brain to think and its empty  ) and muscle fatigue are my worst symptoms |
cat... keep up with the B12 with a goal to get to the top quarter of range or over the top. The brain fog/ word recall problems may be related to the low B12. 9 years after initially correcting my B12 deficiency, I still struggle some with word recall, memory, and concentration problems... but this has
greatly improved from its worst. However, these symptoms are also associated with gluten sensitivity.
Cognitive Impairment and Celiac Disease
http://archneur.ama-assn.org/cgi/con...ull/63/10/1440
Most everything that applies to "celiac disease" applies to gluten sensitivity. In gluten sensitivity that presents as celiac disease, the gut is the target organ, but gluten sensitivity can target the nerve, brain, and other organs without targeting the gut.
B12 deficiency and gluten sensitivity have many overlapping symptoms... and often occur together in the same person. You have symptoms and clinical evidence of both. (Low B12 level with parietal cell antibody, antigliadin IgG antibodies).
Gluten sensitivity is associated with neuromuscular problems, and they can be sporadic. There are a few articles in particular that come to mind by Dr. Marios Hadjivassiliou, the leader in gluten related neurological disease. Gluten ataxia itself can cause wide ranging symptoms, some of which fit what you describe.
Here is an accounting of Dr. Hadjivassilou's articles, with a couple excerpts that highlight the importance of a positive antigliadin IgG:
http://jccglutenfree.googlepages.com/halloffame
Of particular interest might be these articles:
You may have to register to get the full text of a couple of these, but if you send me your email addy via pm, I have most of them as pdf files that I could forward to you. The full text articles explain more in terms of patients individual symptoms than you find in the abstracts.
Neuromuscular disorder as a presenting feature of coeliac disease. Dec 1997
Free on Pubmed:
http://www.ncbi.nlm.nih.gov/pmc/arti...v063p00770.pdf
Headache and CNS white matter abnormalities associated with gluten sensitivity. Feb 2001
Myopathy associated with gluten sensitivity, Dec 2006
Gluten ataxia in perspective: epidemiology, genetic susceptibility and clinical characteristics. Mar 2003
Free full text: http://brain.oxfordjournals.org/cgi/...full/126/3/685
Absolutely give a gluten free diet a trial. It must be a strictly gluten free diet, and it could take months to a year to see improvement...although my daughters neurological symptoms (including leg weakness, leg drag, limp body fatigue, drooping eyelids) all resolved within a couple of months. In the beginning she had fleeting episodes occuring months apart, eventually as often as several times a week, but they would last only for short periods of time... anywhere from 3-30 minutes. Near the end I could see very subtle symptoms always... in her gait... with bigger episodes coming and going.
Cara