Hello and welcome to NT.

Do call the doctor it could be a reaction to medications.

However, I have full body RSD. 7 years into life with RSD my body would itch where ever pressure was applied. It drove me crazy the itching was never ending. There was no rash or redness just uncontrolable itching. I called my PM doctor who though it was my RSD but wasn't sure. He sent me to a allergist who understands RSD and said. The communication between the nerves and the small part of the brain they communicate with when telling the skin to itch was messed us. The brain was getting signals to itch and there we no real reason to itch. I take 2 mg of Periactin 2 x day if I'm flared and once a day if my pain is under control. I have tried to stop the medication all together and a couple weeks without any Periactin and the itching returns.

Keep in mind RSD/CRPS has different affects on all of us. What works for me may or may not work for anyone else. I wish you the best of luck in helping your friend. Being a good friend is so important.

Take care,
Sherrie