Hi Tom,
I have been on 4.5mg of naltrexone for 5years, 4 months. I won't say I have not progressed but my PD meds are still in the low range. I am tremor dominant I guess, no stiffness yet. Actually, I have cut back on Mirapex by half because of ankle swelling. My Sinemet 25/100 remains at 1.5 to 2 tabs a day. Also I have been taking Q10 up to 1200mg/day at the suggestion of my Neuro (she still doesn't know I take LDN). She now wants me to stop Mirapex and start Requip. But will Requip still cause ankle swelling? She also mentioned Azilect. These are two expensive drugs which the jury is still out on from what I've been reading.
As far as LDN is concerned, I base my hopes on it from the work that Dr. Hongs Pharmacology Group has done at the NIH.
http://www.fasebj.org/cgi/content/full/19/6/550
If one scrolls to the very bottom of the paper, they show journals that publish reports on naloxone (LDN), DXM etc. Most of the older pubs are free to read.