There have always been reports of B6 as a cause of neuropathy, but some reports don't even include the doses people might have been using.
This report does give doses and is from 2005:
Quote:
Ned Tijdschr Geneeskd. 2005 Nov 12;149(46):2545-6.
[How much vitamin B6 is toxic?]
[Article in Dutch]
Katan MB.
Wageningen Centre for Food Sciences en Wageningen Universiteit, afd. Humane Voeding, Bomenweg 2, 6703 HD Wageningen. martijn.katan@wur.nl
Comment in:
* Ned Tijdschr Geneeskd. 2005 Nov 12;149(46):2541-4.
* Ned Tijdschr Geneeskd. 2006 Feb 4;150(5):277; author reply 277.
* Ned Tijdschr Geneeskd. 2006 Feb 4;150(5):278; author reply 278.
Vitamin B6 (pyridoxine) causes neuropathy at intakes of 1000 mg per day or more, which is about 800 times the daily intake from foods. There have also been occasional reports of toxicity at intakes of 100-300 mg per day. The US authorities set the no-observed-adverse-effect-level at 200 mg per day and the safe upper limit at 100 mg per day. A report of neurotoxicity in 2 patients who had taken 24 mg and 40 mg of vitamin B6 per day respectively, may be coincidence rather than a true toxic effect of such relatively low doses. However, physicians need to remain alert to high intakes of vitamin B6 as a cause of unexplained neuropathy.
PMID: 16320662 [PubMed - indexed for MEDLINE]
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from
http://www.ncbi.nlm.nih.gov/pubmed/1...&ordinalpos=18
Many studies echo this:
Quote:
Ann N Y Acad Sci. 1990;585:250-60.
Vitamin B6 in clinical neurology.
Bernstein AL.
Department of Neurology, Kaiser Permanente Medical Center, Hayward, California 94545.
Many conditions in clinical neurology may be responsive to pyridoxine as a therapeutic agent. The current difficulty is in trying to isolate the conditions that are most likely to respond. Treating seizures is a major part of a neurologic practice. Our current therapeutic agents are only partially successful and limited by multiple side effects. One problem is that patients often have to take these agents for an entire lifetime, further raising the risk of toxicity. If pyridoxine supplementation can improve the efficacy of currently used medications, it will be gladly accepted into our therapeutic arsenal. Headache, chronic pain, and depression all appear to run together in many of our patients. The observations that serotonin deficiency is a common thread between them and that pyridoxine can raise serotonin levels open a wide range of therapeutic options. Small studies have been carried out with mixed success. Comparison with amitriptyline in the treatment of headache appears to show about equal efficacy, although side effects would be expected to be more of a problem with the amitriptyline. Behavioral disorders are relatively common and continue to be a major problem, disrupting the lives of the patients and their families. Current treatments are not acceptable to most people because of the risk of side effects with long-term usage. If, as Dr. Feingold suggests, many of these problems are caused by "toxic" exposures to chemicals that are pyridoxine antagonists, supplementation at early ages may reduce the incidence of hyperactivity and aggressive behavior. This raises the question of safety. Is pyridoxine safe for long-term use in large segments of the population, including children? The studies on children with Down's syndrome and autism, utilizing much higher doses than are used for other therapeutic purposes, seem to indicate relative safety if carefully monitored. Studies involving large population groups with carpal tunnel syndrome, all adults, using 100-150 mg/day have shown minimal or no toxicity in five- to 10-year studies. Women self-medicating for PMS taking 500 to 5000 mg/day have shown peripheral neuropathy within one to three years. It would appear from this retrospective analysis that pyridoxine is safe at doses of 100 mg/day or less in adults. In children there is not enough data to make any sort of suggestion. Because the major neurologic complication is a peripheral neuropathy and the causes of this condition are myriad, pyridoxine may cause neuropathy only in patients with a pre-existing susceptibility to this condition.
PMID: 2162644 [PubMed - indexed for MEDLINE]
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Everyone is different. The only way you will find answers to your particular situation is to stop all B6 intake for several months, and see if your PN improves (studies say it does for toxicity). If not, the other factors may be present for you.
I have used P5P 50mg for almost a decade and never had any problem but instead have had nice improvement in my carpal tunnel issues.
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