Pathophysiology of the systemic inflammatory response after major accidental trauma

http://www.sjtrem.com/content/17/1/43

"Also, the ability of the monocytes to produce cytokines is impaired following major trauma. This has been shown in vitro where monocytes from trauma patients were stimulated and afterwards showed a reduced production of cytokines. Thus, following major accidental trauma the monocytes do not show a biphasic pattern. In contrast, the function of monocytes is continuously decreased."

S.