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Originally Posted by breugger84
right, but if u read a little more carefully you'd understand that the heartburn medication itself may be causing more insomnia. because it's cutting off the acid used to absorb the other psych meds i take.
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I don't believe that stomach acid enhances absorption of medications.
But stomach acid CAN affect negatively some compounds. This is why peptides are not given orally, since stomach acid breaks them up/digests them. Some drugs are enteric coated for this reason. Peptides are small proteins, and the bonds between the amino acids are broken by acid.
Also many people don't know this, but Prilosec has to have a basic non acid vehicle to be used orally. So does Prevacid. They are inactivated by stomach acid. We add bicarb to them when making them into liquids. The Prilosec beads(caps) and tablets are enteric coated.
This wiki explains it:
http://en.wikipedia.org/wiki/Omeprazole
You may notice motility changes when going off or on SSRI drugs like Lexapro. Since this drug increases serotonin in the synapse, it affects gastric functioning for some people. Some people have nausea/vomiting on it or diarrhea. Serotonin is the main neurotransmitter in the GI tract.
Here is an article explaining drug absorption, where most is accomplished in the small intestine. By the time drugs reach the intestine, the acids in the stomach have been neutralized by the pancreatic bicarb that is provided by the pancreas.
http://www.merck.com/mmpe/sec20/ch303/ch303b.html
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However, whether a drug is acidic or basic, most absorption occurs in the small intestine because the surface area is larger and membranes are more permeable (see Pharmacokinetics: Oral Administration).
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Solubility in water, is the most critical factor for absorption, but even then, some insoluble things do get thru. Giving highly lipophilic drugs with a fatty meal, can help absorption of this type.
I have not been aware of drugs needing acid to be absorbed...I wonder who told you that.
In fact long term use of PPI drugs leads to gas and more reflux.
This is because the protein you eat is not digested properly and is fermented by bacteria in the intestine instead forming gas.
The gas then come back up or down depending along with diarrhea for some people. This is why those side effects are listed for those drugs. Gas coming back up as a belch, will also reflux food if it is present.
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Weezie looking at petunias 8.25.2017
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