Yes, the body can begin to need more and more. If you've ever known anyone with pain issues, it's the same with pain meds.

Well, that kind of scares me. Why not try the increased dose during the day first, so you see if you have increased weakness?!!! If you try it at night, and have signs of a cholinergic crisis (increased weakness) while sleeping, it could be very dangerous. If it works okay during the day, then taking it at night should be fine. Ask your neuro about that!

And there's also the thought that when that 90 mg. wears out in the middle of the night, you will be much weaker. Your body may "wake you up" and need more.

I know that not a lot of doctors like to give Mestinon Timespan at night but what if you talked to your neuro about trying that at bedtime?

I hope you can get it all worked out.

Annie