You guys are smart! But I have a very dumb question. When everett mentioned the "gut" it reminded me of an age-old qestion I have had - constipation. After PD and all the meds I take, it has of course been worse.

My question is if your colon was holding toxins from food, environment, or meds due to constipation; would that have a toxic effect on the brain (especially one with a BBB defect)?

Peg