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Originally Posted by tkrik
I can't seem to find anything about CCSVI and spinal cord lesions.
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The venous problem triggers the breach of the blood-brain barrier, therfore allowing immune cells into the CSF, where they cause damage, whether that be in the brain or the spinal cord.
See this presentation by Dr. Simka: starting at slide 6 he shows how CCSVI could lead to breach of the BBB and the initiation of an autoimmune process.
Also check out
this link which says:
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It has been hypothesized, moreover, that pathological refluxing venous flow in the cerebral and spinal veins might increase the expression of adhesion molecules by the cerebrovascular endothelium. This, in turn, could lead to the disruption of the blood-brain barrier, and in these settings an autoimmune attack against myelin-containing cells could be initiated.
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