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Old 11-25-2009, 06:39 PM
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mrsD mrsD is offline
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mrsD mrsD is offline
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Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Lightbulb

It is hard to say how much Metronidazole would be absorbed.
The gel would facilitate it, I'd imagine.

I don't think enough would be systemic to be a factor, but, you never know with drugs:

Quote:
Pharmacokinetics

Topical administration of a one gram dose of METROGELŪ (metronidazole gel), 1% to the face of 13 patients with moderate to severe rosacea once daily for 7 days resulted in a meanąSD Cmax of metronidazole of 32ą9 ng/mL. The meanąSD AUC(0-24) was 595ą154 ng*hr/mL. The mean Cmax and AUC(0-24) are less than 1% of the value reported for a single 250 mg oral dose of metronidazole. The time to maximum plasma concentration (Tmax) was 6-10 hours after topical application.
http://www.rxlist.com/metrogel-drug.htm

Notice only 13 patients tested.
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