One of the things about this approach that I will be getting into once I catch my breath is that these starting conditions of neuroinflammation and disrupted stress response make a big tent which can house many of the other explanations that have been proposed. For example, rotenone is bad news. But LPS synergizes with it and it all becomes very bad news. Metals such as mercury and aluminum are longtime suspects. LPS can make you allergic to them as well.

A leaky BBB is bad news, too. Chronic inflammation from LPS hypersensitivity increases its leakiness as well a that of the gut. A poor stress response adds to inflammation. It also causes constipation. So one has constipation, a leaky gut, failing BBB, and toxins in the brain.

Things start to fall into place very rapidly. More men than women get PD? Estrogen protects against inflammation. Farmers get it more than others? They work in a cloud of LPS laden dust.

There are a doxen more things like that. Observations that any valid explanation has to explain. I'm sure there will be some that elude me, but so far most things fit. Stay tuned for the next installment.