I am sure there are differences. I imagine that chronic use of any medication may make us need ever increasing dosages.

Not every one gets paradoxical pain. I actually felt LESS pain when I went off fentanyl, and increasing the dose of it, would have likely caused more pain. I can't explain that phenomenon. I also felt more anxiety and pain on meds intended to decrease anxiety. I have a lot of paradoxical effects to meds. Just not wired right I guess. Assumptions are made by docs that all people function the same. This is not true. 10% of Caucasians lack the
D26 enzyme which metabolized a lot of common drugs such as SSRIs and antipsychotics, such as abilify and zyprexa and risperdal.

Tolerance Withdrawal should be relieved by upping the dose, but understand that this will result in ever increasing dosages. Paradoxical Pain is not relieved by upping the dose.

Interdose Withdrawal is when you experience withdrawal symptoms when the drug starts to wear off. You have to look up the half life for each drug. I was sick for months with interdose withdrawal until a doc figured out that I was experiencing that. That was back in 2000, and involved a dose of xanax at bedtime only. I would wake at 3am in incredible distress. Years later, I ended up on klonopin for sleep.....bad idea. That has a longer half life, up to 80 hours. You don't get into major withdrawal until 3 days after you quit. Ugh. It takes a good 30-60 days to get it all out of your system as it is lipophilic (stored in fat cells), then your nervous system has to reprogram itself. Interdose withdrawal can take place on a short acting medication or if you metabolize your long acting shorter than the script. Like 2 days for fentanyl versus 3.

Whenever people have unexplained disease, it makes sense to look at meds.

At least now, I have a good idea of my disease level, and can make sense of my lab work, as far as correlating symptoms to labs.

A lot of disease is iatrogenic, but you can't know what is what, if you are reacting to meds. I don't know what you have, if you have PN, a spinal cord stimulator is for central pain, and PN may go unrelieved. This is all fairly new technology. Don't get rushed into any procedure until you have fully researched it, and have answers as to why you are suffering from pain. Keep in mind, that 5 different docs may give you 5 different opinions.