Welcome Karen!

I also found that for the first year or so that I felt as if the Tysabri was "wearing off"

It's much better now, or I have gotten used to it. Hard to say since I am coming up on #34 and things tend to bleeennnd in after a few years!

I missed one infusion due to appendicitis and removal of the offending organ, and I thought it would affect me, but honestly, I was in so much pain from the surgery, and the recovery, that I was glad I didn't have to deal with infusion on top of everything else! I had major abdominal surgery because they didn't know what it was (unusual presentation)

I don't think there is much you CAN do about it. The drug company and most docs are not likely to change the schedule and give it to you any earlier than 4 weeks after your last infusion, especially now with all the new PML news. What exactly do you feel when you feel it wears off?