Quote:
Originally Posted by Benstead3189
Hi everyone,
New here but have been reading all your threads and find myself questioning my original thought process! i need your help.
I was diagnosed with Early onset about 10 years ago and am currently taking Sinemet CR half tabs 25/200 two three times a day plus mirapexin 1x 0.7mg three times a day and mirapexin 2x 0.18mg two three times a day.
I am finding that I am not getting the same relief I once had and after about 3 hours I am offline again, sometimes they don't even work at all.
I came across Mucuna and have heard some great things about it,then I found threads on Zanadopa and thought should I only take pure Mucuna?
Basically I feel I need more than I am getting and have been taking too many sinemet ( which I have now stopped doing!) I wanted to try a natural alternative alongside the Sinemet CR, can anyone advise me is Mucuna safe or safer in its pure form than Zanadopa?
many thanks
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I am in my 7th year, and I too have been taking 3 x 50/200 Sinamet CR daily..2 x .5 Mirapex, and Amantadine 3 x 100mg daily..Ive been on the CR and Mirapex for two years..Had to add Amantadine this year beccause of tremor, dystonia and dyskiesia in my right leg..Recently I have been having the same problem as you..Somedays my meds would work, and somedays they dont..I went through 4 straight days two weeks ago, where I took my meds, and nothing happened all day long..Finally, I started taking 3 - 25/100 Sinemets inbetween doses to get back on, and still had some tough moments throughout the day..I have seen my neuro three times in six months, but the first two visits I was doing ok..The third, and most recent visit, he finally saw me when I was at my worst
He changed me over from Sinemet CR to Stalevo 50/200 three times daily, and the Stalevo keeps me on from 7:00 AM untill midnight, and has worked consistantly everyday..And it is quality on time..This is the closest thing to a "Sinemet Honeymoon" that Ive ever experienced..When I walk, it is vigorously, rather than shuffle or limp..I had no idea what my meds were covering up untill they didnt work anymore
I think the deal is, when the body starts breaking down more of the levadopa before it crosses the blood brain barrier, you need more and more Sinamet to get the same effect..Because Stalevo has Comtan in it, to block the receptors from breaking down the levadopa, you get more out of less, or the same amount of Sinemet..If that is the problem, then what I know about this so far tells me that, Im not certain that Zandopa is the answer..And Im not sure because I dont know if the body breaks down the natural dopamine in Zandopa, like it does with Sinamet before it crosses the blood brain barrier
Maybe Im all wet, bit it's food for thought