Magnate
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Join Date: Aug 2006
Location: Queens, NY
Posts: 2,857
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Magnate
Join Date: Aug 2006
Location: Queens, NY
Posts: 2,857
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One can get--
--very similar small-fiber neuropathy symptoms both from the "traditional" "die-back" type of small-fiber neuropathy, in which the most distal nerve tips are damaged first, and from gangliopathies, which mean the cell bodies in the dorsal root sensory ganglia get damaged or die.
Generally with the latter, there is less likelihood of a skin biopsy showing a length dependent die back; that is, of the nerves at toes/feet showing more damage than those at mid-calf than those at mid-thigh and so on. Gangliopathies may cause diffuse damage, but more globally--nerves all over the body are affected at more or less equivalent rates.
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