Quote:
Originally Posted by glenntaj
--very similar small-fiber neuropathy symptoms both from the "traditional" "die-back" type of small-fiber neuropathy, in which the most distal nerve tips are damaged first, and from gangliopathies, which mean the cell bodies in the dorsal root sensory ganglia get damaged or die.
Generally with the latter, there is less likelihood of a skin biopsy showing a length dependent die back; that is, of the nerves at toes/feet showing more damage than those at mid-calf than those at mid-thigh and so on. Gangliopathies may cause diffuse damage, but more globally--nerves all over the body are affected at more or less equivalent rates.
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Amit, I hope you don't mind me jumping in on your thread, but yes, I am experiencing similar pains to yourself and wanted to run my question past Glenn following his response to your post.
Glenn, As you may remember, I too had the acute onset global burning and increased sensitivity/pains in hands etc. What I would like to figure out is, (without the help of any doctors or Neurologists it seems, as we don't do skin biopsy in NZ and as all blood & basic physical neuro exam results are 'normal' I'm now on my own, apart from this forum) anyway, my question is: the pain starts in hands and also my feet (shooting/aching), so, 'distally' and in a length dependent fashion yes, but then within days the burning started, first in the thumb, then hands, forearms then everywhere within a couple days, which indicates 'non'-length dependent, correct? so, is it possible to have a length dependent AND a non-length dependent problem starting within days of each other?
What I am hoping is the apparent damage is *actually* in the peripheral nerves (or the nerve endings) which may in time regenerate, not the Dorsal Root Ganglia. But being that my burning is pretty much all over in varying degrees, as we have discussed before, it is likely to be a DRG problem? or is it at all possible that this global burning *could be* truly peripheral in nature, indicated by the distal 'die back' nature of the hand/feet pains? I hope I'm making sense.
As I know it came on quickly & globally for yourself, and you have made a partial recovery so far. Has it ever been verified that it was a DRG problem, or a direct reduction in nerve fibers locally ? I think I read you did have a reduction in epidermal nerve fibers, does this 'rule out' ganglion involvement in your case?