NeuroTalk Support Groups - View Single Post - Vitamin B6 Pyridoxine/P-5-P information:

mrsD · 12-18-2009, 07:42 AM

I found this article this morning...it is very interesting:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1297572/

Quote:

Vitamin B6 deficiency results in adverse health consequences, including hyperhomocysteinemia [1] and possibly arteriosclerotic lesions [2]. We have reported that the degree of disease activity is associated with vitamin B6 indices in patients with rheumatoid arthritis [3,4]. Bates and colleagues reported suboptimal vitamin B6 status in inflammatory conditions and in the acute-phase response in the elderly population [5]. These observations have attracted attention partly because vitamin B6 deficiency and several markers of inflammation were both found to be independent risk factors for thrombosis [6,7]. Although several clinical trials and epidemiological studies have demonstrated the associations between vitamin B6 and inflammatory diseases, the association between vitamin B6 status and inflammatory markers has been contentious, and the cause-effect relationship between these two has not been elucidated....
Results:
In the human study, plasma pyridoxal 5'-phosphate concentrations were significantly lower in patients than in healthy subjects (with about 50% lower). This observation was comparable to our previous finding [3]. In contrast, no difference was found between patients and controls in erythrocyte pyridoxal 5'-phosphate or erythrocyte aspartate aminotransferase or 4-pyridoxic acid levels. No difference was found in concentrations of plasma folate, red blood cell folate or plasma vitamin B12 between patients and controls.