I have been on Cymbalta for about a month and a half. I started with
30mg/day for one week followed by 60mg/day, the recommended maintenance dose. There hasn't been a time when I thought, finally it's working. There probably has been some subtle psychological improvement. I think it has helped more with minor neuropathic pain. I have read others who said it worked immediately but that has not been my experience. I suppose everyone will have a different reaction. My doctor said to give it time to work. Apparently a lot of people give up because they don't see an immediate result. Hope that helps.