Welcome and hope you find lots of support, info and hugs here. I know I have.
I suffer from leg spasms. They've been a bit calm lately, but I know what you're describing. I'm on zanaflex capsules (my neuro told me the capsules work faster than the tablets). He told me to increase the dose if the spasms get worse, that I can take up to 24 mgs per day.
I was on baclofen and gabapentin before I switched neuros. I also was on monthly IVSM infusions. This neuro took me off of all of it...told me my brain was literally being fried.
I just got weaned off of Cymbalta for neuropathic pain, but I might have to go back on it, since the pain has increased.
Anyway, my neuro is suggesting botox injections for the spasms if they give me the kind of pain I suffered from. It's been muted, but I find that it still awakens me at night and I also can't stand for more than 20 min before they begin to tighten up and complain.
You are on quite a bit of medication...do you do stretches? That is stressed by my neuro. It helps a bit. I use a yoga strap. There is some info on stretching that I found useful on the Nat. MS Society's web page.

Good luck, and keep looking around here...I have found this spot a very good place for information from people who've been where I'm traveling...and I'm sure you will, too.