my posts are being raised from this article, which is an editorial.
AChe is Acetylcholinesterase - the enzyme regulator or inhibitor.

Nicolaas I. Bohnen,
MD, PhD
Roger L. Albin, MD

Neurology

® 2009;73:256–257

note this observation from the authors:

The authors describe prominent and widespread reductions in cortical AChE in the subject groups with dementia and significant reduction of cortical AChE activity in early drug naïvepatients with PD. These findings agree with postmortem evidence suggesting that basal forebrain cholinergic system degeneration appears early in PD and worsens with the appearance of dementia.

my question:

isn't that what one would expect if one were considering acetylcholine in the diagnosis? they have parkinson symptoms by the time they are diagnosed, which would mean their acetylcholine could be high and anticholinergic activity disabled and not working.

then we go on meds, and struggle to keep it balanced, but in advanced patients the meds are less effective so the acetycholine levels go back up as anti cholinergic acitivity decreases once again.

??
paula