The other point we should not forget is damage to the BBB seems to be involved in other neurological diseases. In my post
http://www.pdonlineresearch.org/resp...ain-barrier-pd
I listed MS, ALS, AZ etc as diseases that all seem to involve BBB damage,
and research into this topic could kill several birds with one stone.
I came across today a paper which discusses MS as involving BBB damage, published as early as 1993, so the theory has been around for some time.


http://www.ncbi.nlm.nih.gov/pubmed/8...m&ordinalpos=7

The mechanism for the initiation of blood-brain barrier damage and intrathecal inflammation in multiple sclerosis (MS) is poorly understood. We have recently reported that levels of tumor necrosis factor-alpha (TNF-alpha) correlate with blood-brain barrier damage in patients with active MS

Ron