Jamming cell’s protein disposal shows how system works
CAMBRIDGE, Mass. (October 26, 2009) –Whitehead Institute scientists have determined that a protein known as YOD1 plays a critical role in the disposal of misfolded cellular proteins. The inability of cells to properly remove errant proteins is associated with multiple disorders, including neurodegenerative diseases such as Parkinson’s and Alzheimer’s.

The researchers identified YOD1’s role by blocking its function, a manipulation that halts the elimination of several misfolded model proteins entirely. The finding, reported this month in Molecular Cell, should help bring greater understanding to this vital but complex cellular process.

http://www.wi.mit.edu/news/archives/2009/hp_1026.html