Akimbo, Raglet makes a good point. Are the white spots there all the time? If so, they can be biopsied. I have white spots too, have for probably 2 decades. No one really knows what they are. My mom had vitiligo (supposedly). Docs say this is not vitiligo, and it isn't as bad as my mom's pigment issues were. I have not had a biopsy on this either, I just got sick of all the tests, lol.

Also, your conditions could be related, Raglet. The CREST to Scleroderma continuum does include PN. PN is more common in this than once thought. The same vasospastic disturbance of Raynauds can also cause PN, or visa versa, (chicken or the egg situation). I too, have vasospasm, but not to the extent of things turning blue. My hands and face hurt badly when exposed to cold,like an ice cream headache. My feet are cold and dead anyway, so not much bothers them. Nurses at the infusion clinic are aware that vasospasm happens and when it does, getting an IV in is tough. Even if well hydrated. They wrap my arm in warm compresses, they call it a spa treatment, lol.

PN is being recognized now, as being responsible for many of the problems seen in autoimmune disorders.

Also, my ENA at this point is negative, ANA is highly positive, so I am sitting in no man's land as far as the known diseases, except for the salivary gland biopsy, and that is + in many if not most autoimmune disease. Raglet how is your ENA panel? My neuro says that there are many yet to be identified antibodies that the ENA won't show, but ANA will be +. That said, you can still be seronegative and have autoimmune disease. I was seroneg for a decade.

Sounds like we have some commonalities. I am going back to bed, my 'migraine' is not going away. I guess I overdid it during the holidays.