Hi Lindy,

Thank you very much for such detailed & prompt advice. I live in the UK and my neuro is not a specialist in movement disorder. Self-deprecatingly he calls himself a “jobbing” Neuro. I have already re scheduled my medication time table and take Sinemet 62.5 (containing 50mg of Levodopa and 12.5 mg of Carbidopa) at shorter intervals of 6 am- 9am-12 am-2 pm-6pm and 10pm. The first dose however is a hefty 100 mg. None of this has given me any relief, instead increasing vertigo, freezing and onset of serious rigidity of my leg muscles and abdomen muscle group. Sadly I cannot envisage taking additional drugs, as my Chronic Fatigue delivers malaise, arrhythmia and muscle spasms. I am aware and to some extent familiar with dietary restrictions.

The possibility of my illness being something other than PD has been proposed & dismissed as I did respond the Levodopa therapy at the beginning and its effectiveness though limited, lasted till now . That its wearing off effect could make one feel worse is new to me and fits the picture. I have been prescribed domperidone but reluctant to take it (I understand it enables swifter emptying of the stomach) as I take Zopiclone and Tamazepam combined to get some sleep at night and adding domperidone scares me. I am not familiar with the “uptake of sinemet in the brain” being insufficient. Are you talking about dopamine agonists like Rasagiline which I had to give up after a 21 day trial when the symptoms became worse and have remained so ever since. My neuro tells me that I am under-medicated. I have been keeping a Sinemet diary and hoping this distressing experimentation would bring some answers.

I am wondering if there are PWDs with further insights that would help.

Thank you again for your advice.

Kenki <<<