cyclelops - I am really lucky when it comes to my ENA testing, and I just seem to make loads of antibodies. I really appreciate this, as so many people struggle with getting a dx, while this has never been a problem for me as I have classic blood tests for lupus, antiphospholipid syndrome, and sjogrens syndrome. From memory I have positive ANA, anti-ds-dna's, SSA, lupus anti coagulant, anticardiolipin antibodies, low level RNP, and more that I have forgotten. I know it seems strange but I really do feel fortunate to have so many positive antibodies, plus supporting tests like low C3 & C4, low wbc, etc etc, as it gives me a very clear diagnosis which I really appreciate. From memory my anti ribosomal P was also positive (which is associated with cns disease) but I only had it tested once as it had to be sent to a lab in another country.

I think that how autoimmune disease affects us varies a lot from individual to individual. For me, I don't feel that my PN is associated with my circulation problems, but then it may well be for other people. We are all just so unique when it comes to how our disease is expressed which makes it a real challenge in finding effective treatments.

cheers
raglet