Raglet, in addition to the high ANA, I have a low C4 and elevated CRP. I think there are lots of antibodies that still need to be tested for. I have had the basic ENA. Given I have a nucleolar pattern (at times), I am surprised nothing came up on ENA. They have never mentioned the others and I don't think they did anticardiolipin or some of the other things you mentioned. I had 4 normal pregnancies so I assume I don't have antiphospholipid issues, unless they developed later. I did have the neuronal antibodies done 5 years ago, and it is worth a repeat I think.

I don't know if I have circulation issues, but given the cold feet, migraines, labile BP, and vasospasm, I assume I do. I try not to think about it.

They did not want to test for any antibodies this last time, due to IVIg. I wonder how they can monitor disease without testing. Hmm. They did say next time they will run the ANA and ENA. I will ask for the other antibody tests then. I think because I had Lyme, they are a bit reluctant to nail me with the -mab drugs or anything that causes severe immunosuppression. It is a double edge sword. I feel really rotten lots of days.

You have a boatload of autoimmune issues! What are you being treated with and does it help?