Thread: Parkinson Disease Dementia - PDD
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Old 01-04-2010, 10:57 PM
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Our problems are much more complicated than a lack of dopamine...

History of falls in Parkinson disease is associated with reduced cholinergic but not nigrostriatal dopaminergic activity

N Bohnen, K Frey, M Muller, R Koeppe, M … - Society of Nuclear …, 2009 - Soc Nuclear Med
J Nucl Med. 2009; 50 (Supplement 2):1235
Nicolaas Bohnen1, Kirk Frey1, Martijn Muller1, Robert Koeppe1, Michael Kilbourn1 and Roger Albin2

Conclusions:

These data indicate that unlike nigrostriatal dopaminergic denervation, cholinergic hypofunction contributes to increased fall risk in PD. Thalamic AChE activity also had a significant inverse relationship with the absolute number of falls. In this respect, thalamic AChE activity in part represents the cholinergic output or projection area of the brainstem pedunculopontine nucleus (PPN), which is a locomotor nucleus involved in gait control.

http://jnumedmtg.snmjournals.org/cgi...Abstracts/1235
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paula_w (01-05-2010)