Paula,

Thank you for clarifying the drug class of Amantadine; I forget that it is not truly an anticholinergic. Also, the book you link to is a good resource for reviewing drugs in great detail and from a historical perspective. I am beginning to note that many times I read what amounts to myth on drugs that have been around for some time, like Levodopa efficacy over the long term, disease progression and drugs, etc. This has given me some peace of mind.

So, with Amantadine acting as an anticholinergic...I wonder if it can really then be lumped with other drugs firmly in that class as showing a more rapid decline in mental function?

I also wonder if many of us need a combo of Amantadine or anticholinergic and dopa stimulation (agonists or levodopa) based on subtypes? In other words, if you are more rigid should you have more of an anticholinergic and less levodopa? I wonder if playing around with these drugs to restore more of a natural balance is more beneficial to us in both symptom control and longer term efficacy of drug treatment?

Laura