I think it depends on the person. We did 3 rounds of 5 day IVSM and 7 rounds of oral steroids last year and the final round of IVSM was to prove that steroids do not work for me at all. Aside from making me extremely ill, and causing a few too many blown veins they seemed to have no effect or a worsening effect for me. My very first round on my very first day I woke up actually feeling my legs, and my feet and it was great....then the second round made me sick and it was downhill from there.

After the last round the neuro vowed never to give me Solumedrol ever again... which works out pretty good with the decision to start the TY.

BUT... Other people respond wonderfully, and some people respond a few days after stopping, so like everything else with this darn disease I think it is a wait and see game.