Hi,

Sorry to hear about the discomfort. A couple things I wondered as I read your post...what pill are you taking before the worsening of symptoms? I take it that you mean Stalevo? When do you take the Azilect and how long have you been taking it? I sometimes question the newer drugs like rasagaline and agonists when it comes to weird side effects. I experienced deep joint pain from taking it and had to stop- this is an effect in younger patients...problem is that it did not entirely go away. :|

I have also experienced having too much dopamine in my system at once when on Mirapex, Azilect, and Sinemet- this brought on really painful leg cramps; I've read of this in other forums as well- I think it's an "over peak" dose dystonia. So, I'm wondering if your med combo is too much at once or taken too close together, or if it's one drug thrown in the mix that is the culprit. I try isolating, or taking my drugs apart a little separately to pinpoint if one thing seems to trigger it.

One last thing. Comtan inhibits an enzyme that breaks down levodopa, on its own, it does absolutely nothing to help alleviate our symptoms. So, with that in mind, it's not surprising to read that a side effect is onset of new movement disorders!! This make sense given that the drugs mainly work on helping with dopamine transport and there are several other neurotransmitters at play which are then thrown even further off balance and maybe result in new 'symptoms' that are really only related to drug treatment. Try talking to your neuro about it.
Laura