Receptor gene expression activation in brain resulting from single inflammatory event:
http://www.definitivemind.com/2010/0...mmatory-event/
Chronic Microglial Activation After an Inflammatory Event
by Romeo Mariano, MD on January 10, 2010
Systemic lipopolysaccharide (LPS)-induced microglial activation results in different temporal reduction of CD200 and CD200 receptor gene expression in the brain...
J Neuroimmunol. 2009 Sep 29;214(1-2):78-82
Authors: Masocha W
LPS activates microglia, which are normally maintained in a quiescent state by CD200-CD200 receptor (CD200R) interaction...
...LPS-induced changes in CD200-CD200R equilibrium might keep microglia chronically activated. Minocycline does not effectively inhibit microglia activation induced by high-dose LPS.
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This article demonstrates that chronic microglial activation can occur via a single inflammatory event. Microglial activation producing pro-inflammatory cytokines is one of the pathophysiologies behind a diverse group of illnesses...
LPS is a substance used in psychoimmunology studies to induce a pro-inflammatory immune response. When introduced into the gastrointestinal system, it activates the sympathetic nervous system via vagal sensory neurons, which monitor for the presence of pro-inflammatory cytokines