Well, with respect, I have to come out come out the other way, at least in terms of my own experience. My friend MsL had an earlier version, known as Pamidromate. I have used without incidence a newer form, brand name Zometa (Zoledronic Acid). While at one time there was an FDA warning linking it to possible atrial fibrialtions, that was withdrawn on 11/12.09. http://www.nlm.nih.gov/medlineplus/d...s/a605023.html

I have been taken infusions of Zometa for the past 2-3 years, and while it by no means hasn't taken care of everything, it has resolves the worst of my deep, "bone crunching" pain. However, good pain mangt. docs require a written pre-clearlance from your dentist, where people who have required major dental work, e.g. root canals, within a few months of taking it have a tendency to develop something evil called jaw necrosis. In addition, it can only be given to people with normal kidney functions, so a basic metabolic blood panel is typically taken and analysed within 7 days prior to each 15 minute infusion.

As I understand it, the initial treatment starts out with three monthly infusions: I didn't get relief until the third one. Thereafter, boosters are given every 6 to 12 months, as needed. Hope this is helpful.

Mike