Hi Im new....not new to MG but new to forum. ive had MG since 1990 but ,of course, took awhile to diagnose. It started in my legs then moved up my body. There have been times when Ive done very well taking mestinon just a couple times a day and my symptoms are only noticable to me, but then.... about 2-3 times a year they get really bad. 60-90 mg every 4hrs and 180mg of timespan at night....this can last weeks to months. Ive noticed ,this time, that more mestinon is not really helping....still relying on my cane for balance with weak legs. Is this because its been so many yrs and Im immune to the med? Or have I just been fortunate all these yrs and I should expect to always have trouble?