Yes, the cold is absolutely horrible, as well as 115 degree heat. I live in southern california and we have wonderful weather here, i had a series of ketamine infusions and was doing great and i went to oregon where it was 30 degrees and it flared all back up and i ended up having to go through more infusions as soon as i got home because of the cold weather. you arent alone the cold weather is horrrrible!!! all the reason to come to LA! (i live in la, and the weather is for the most part really nice) But the rain... oi... thats when the pain kicks in. My doctor alters our medications seasonally- ie winter more meds summer less... kind of nice because my body hasnt gotten adjusted to medications so we havent had to up them because I was used to them.