Reglan is metoclopramide. It is a dopamine antagonist. I can cause tardive dyskenesia and middle age women seem to be most at risk for TD. Zofran is not the same. It is related to SSRIs. In some people, particularly those with dystonia, it can cause movement disorders, but in the vast majority of people, it is generally tolerated well. Phenergan is promethazine, an antihistamine.

All three can cause movement disorders because all of them suppress dopamine. It can exacerbate restless leg, arm, back syndrome. I tried Reglan and Zofran, IV, at the ER, and both caused me to have an exacerbation of my movement disorder, and the Zofran was the worst....unmitigated by pramipexole! I have dopamine issues, so I am not typical.

Some folks do just fine with these meds.

For me they had to use erythromycin. I am doing better now, in the GI dept. and dont seem to need anything...at least for now. Knock on wood.

I believe they can also implant a stimulator?