I just started the Timespan about 2 weeks ago. I take the first one when I wake up, and the second one about 8 hours later. At first the Timespan wasn't giving me enough, and I was so weak all day. Now I'm taking a quarter pill of the quick release when I take the timespan, and about every 4-5 hours throughout the day. But it's so much better not to have the crashing effect when I was just on the quick release and it was wearing off. Tell your Dr. whats goin on....mine told me to start with a quarter pill at waking and add up as needed...so of course I tried a half instead, and ended up with too much...GOOD LUCK!!!

JESS