...but I've been reading and thinking, a dangerous combination

One thing I have been thinking about is the original descriptionof PD in Parkinson's infamous essay of 1817. Given how "noticeable" our condition is and how prevalent, why was it not described sooner?

The traditional speculation has been that the advent of the Industrial Revolution brought new toxins into the picture and that that triggered it, but I wonder.

Another thing that the IR brought was massive, rapid, and sustained change in society. A society can adapt adapt massive and rapid, but sustained (continuing) poses a different problem because adaptation is constant and there is no time for the systems to rest.

The reason I wondered about yo' mama is that stress on her affected the way we developed. And there is research that indicates that the effect can reverberate down several generations.

Then the question becomes what stresses were our grandmothers under and how are they affecting us today. And an even bigger one, do the effects accumulate and get more pronounced with each generation.

Sure are a lot of younger Parkies around then I would have expected....