Interesting article.

It mentions that glutathione decreases by up to 80% in males and does not decrease at all in females after a brain injury.

I wonder if this is a result of progesterone which is not available in males but is in females.

The glutathione is mentioned as being neuro-protective. This is the same characteristic they find in progesterone. Could it be that the progesterone is neuro-protective by maintaining the proper level of glutathione?

The article did not mention anything about glutathione being useful long after a brain injury.

Its use for Parkinson's appears to be as a restorative compound that enables the brain to restore proper function lost due to an improper glutathione process. It is available as a nutraceutical in denatured whey protein (whey protein that has been heated as in pasteurization).

Its more immediate effect from IV infusion appears to be as a mood stabilizer as it appears to function similar to valproate, sometimes prescribed as Depacote. As PCS subjects can tend to be prone to mood disorders, I wonder if consuming denatured whey protein will have the same effect without the needle complication and expense?

My research suggests that B-12, folic acid and trimethylglycine (TMG) are helpful as they support the body's ability to produce Methionine which is necessary in the production of glutathione.

There are those recommendations of B-12 and folic acid that I have been raving about.

TMG is helpful at reducing homocysteine levels but can cause an increase in cholesterol. It is suggested that adding B-6 to the B-12 and folic acid is a safe way to naturally maintain homocysteine levels.

Grains, nuts, seeds, and meats contain small amounts of TMG, so they can be consumed to help with a natural balance of TMG. TMG is destroyed when food is cooked or processed, so the raw grains, seeds and nuts are the best foods for TMG.