thanks mark interesting study,

I tend to dismiss reported cognitive findings in mice as return of instinct, but the regeneration of tissue is interesting
due to my csf leak I have been looking into studies of the fluid as a transmitter

also honey as a potentizer in sugar transported drug

fats eg omega fatty acids as a transporter

this was an interest of mine many years ago when I lived in nz, I applied for a job as a chemical process engineer with a company that was refining manuka essential oil plus other oils and adding it to honey to make a kind of super manuka honey which is effective against msra, I didn't get the job and had forgotten until just now, if I had got the job I would not be typing this post, funny old world ain.t it

also of note is the administering orally in water, in homeopathy there is a theory of dilution eg pure H2O having no trace elements present carries drugs much more efficiently by bonding to the molecules without impairment, since we are 80 % water this seems to make sense

it would be interesting if the BCAAs compounds are present in csf if so what effect they would have in dilution if applied directly into the csf reticular system