Thanks for all the responses. Let me clarify how the Neuro meant what she said. I asked her if it was normal for a few new lesions to show up from time to time on CRABs, and she said yes. But she said it isn't within the expected profile to see a big jump in the numbers from one year to the next (Mine went from around 7-8 to around 15 or so...so basically it doubled in 12 months). She said that kind of a jump indicates the drug is failing in that it isn't controlling the increase in lesions.

As for the symptoms, I have had a lot of mental stuff going on...memory issues, slight confusion, etc...but nothing overtly physical other than periodic fatigue. She and I agree though that the next lesion might hit something I care about, so I would prefer to see no new ones at all...hence the change in meds. She termed it a Copaxone failure...but what she meant was that it wasn't doing what it was supposed to for me and I was one of the ~70% for whom it was not effective.

And Tom, yes, I am riding the MS150 again this year...just did training ride one in the Conoco Phillips series...37 miles out by Katy Mills Mall this morning. Rode faster than I ever have...so even if I have more lesions, at least the spin classes are paying off. Part of it was I was riding angry at MS and the Copaxone for not working...wish I could channel that feeling and use it to go faster every time.

I still have your card and I am planning to call you for that tour when my nephews are in town next time. Will probably be June/July timeframe.

Thanks again everybody...I feel better this morning...I was just kind of anxious and unsure of things after I left the doc's office yesterday. Whatever will be will be and I will just roll with it...