yes, you feel like you've a bout of flu at first: headaches [this can be fixed w/pre-meds and slo infusion rates], the runs, and a lack or attack of appetite. It doesn't last long at all 2 days +/-. I'm infused 2 days a month, and 1/2 way thru the 1st day's infusion my brain feels like I've had 3 double-expressos [which I havn't had], inspite of a whopping Benedryl dose that SHOULD knock out an elephant!

My overall nerve pain drops 2-3 points and my aches 'n pains level goes down as well. Overall, it means I can pretend in a way to have a LIFE! A very useful thing in my book! In a way, it's simpler and more straightforward than lots of meds - my only complaint is I need to get it every month. Some folks are lucky and don't - hope this helps - j