Quote:
Originally Posted by ZucchiniFlower
Conclusions: Although the majority of patients with PD have evidence of a robust parallel decline in striatal dopaminergic and cortical cholinergic activity, there is a subgroup (19.1%) of patients with decreased dopaminergic but preserved cholinergic activity.
Research Support: Supported by the Michael J. Fox Foundation and the Department of Veterans Affairs.
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Just reviewing these posts in trying to warn some PD newbies who are being prescribed Aricept with abandon...
I wonder whether these differences reflect subtypes? For example, those whose cholinergic transmitters have been hit harder end up with presenting more with Postural Gait traits as predominant early on?
Thanks for these great studies, Zucchini Flower.
Laura