Well....I could spend a week on this subject....looking and looking.

So what I did was look up the main product:
glucomannan:

http://en.wikipedia.org/wiki/Glucomannan

To get an actual ingredient list here seems difficult. The ingredients on the first page of that link are vague.

I can see an absorbant fiber like glucomannan helping with removal of toxins in the GI tract. Bowel bacteria typically become deranged and the ratios of good to bad change radically with antibiotic treatments that are common today. So absorbing the toxins that the bad ones create, may help the GI tract itself. We also consume foods that are contaminated with pathogens, these days too.
Plain old psyllium fiber (Metamucil) will do the same thing--adsorb toxins. I've used it myself for this purpose. Another fiber that will do this is Chitosan.
http://en.wikipedia.org/wiki/Chitosan

I really have a problem with supplements that list so many problems cured with their use. What this product may do is repair some damage to the GI tract so the body can absorb nutrients properly. We know that Crohn's and Celiac (gluten intolerance) can damage the lining of the GI tract so that normal absorption of nutrients then fails. This product may help in that way.

But I don't see these "nutrients" being absorbed into the body much, and effecting any changes that way.

I also wonder at the new statement, from Dec 09...to hurry up and order before the "shortage" because of manufacturing changes. Those changes may in effect be a FDA shut down!
Making claims for diseases as that website does, is illegal according to FDA rules.

Another thing.... 500mg for all those ingredients? That is a tiny amount. And those molecules are HEAVY.... large. Sugars and proteins are macronutrients... we consume them in GRAMS, not milligrams.

I find some of the claims that these are absorbed whole, including proteins, rather confusing. Our GI tract does not absorb whole peptides when healthy, if it does, like the gluten peptide it causes antibody reactions.

So as of now, I am totally skeptical. I did search the net and found some people who took this for 3 or more months, and had no effect. Given that the placebo effect is very strong, that result is interesting. At this point I don't see this product being harmful (toxic) except to your wallet.

If you do get results, please continue to post. I am always interested in nutrients, and will keep a small door open on this one.