Thread: SYN115 Phase IIa; positive data
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Old 02-01-2010, 09:22 AM
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Default SYN115 Phase IIa; positive data
Interim positive data from Phase IIa clinical study of Synosia Therapeutics' SYN115 announced

The Medical News, February 2010 01:39
http://www.news-medical.net/news/201...announced.aspx

Synosia Therapeutics today announced interim positive data from a Phase IIa clinical study of an adenosine 2a (A2a) receptor antagonist (SYN115) in Parkinson’s disease.
“We have successfully established that SYN115 is getting into the brain, changing the activity of relevant regions of the brain, and we now have a better understanding of the doses that are likely to be therapeutically useful. Those were our objectives in undertaking the study.”
The Phase IIa trial was a randomised, double-blind, placebo-controlled, cross-over study in 24 Parkinson’s patients using doses up to 120mg/day for one week. The effects of SYN-115 as an add-on therapy to a stable dose of levodopa was assessed using a number of techniques, including functional Magnetic Resonance Imaging (fMRI), clinical ratings such as the Unified Parkinson’s Disease Rating Scale and various cognitive tests.
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