The Bioperine does work. However, people using OTHER drugs may be at risk with it. There are just not very many studies of alot of drugs to show how it alters their absorption too.
I'll give you an example:
The work concerning grapefruit juice... took over a decade to evolve and started with one drug...Calan and expanded to many many drugs, if not MOST drugs out there. Grapefruit juice inhibits Cytochrome P450 which is in the lining of the GI tract. (as well as the liver). It was not understood that this barrier was there, and our drug studies developed doses for drugs based on how people absorbed them. Once you CHANGE that and enhance absorption, then people could get OVERDOSED.
This is what Bioperine does...it also enhances absorption. I did alot of searching a while ago looking for data, and it just does not exist for most drugs. I believe Dilantin was one affected.
Quote:
J Pharmacol Exp Ther. 1985 Jan;232(1):258-62.
Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism.
Atal CK, Dubey RK, Singh J.
Piperine, a major active component of black and long peppers, has been reported to enhance drug bioavailability. The present studies were aimed at understanding the interaction of piperine with enzymatic drug biotransforming reactions in hepatic tissue in vitro and in vivo. Piperine inhibited arylhydrocarbon hydroxylation, ethylmorphine-N-demethylation, 7-ethoxycoumarin-O-deethylation and 3-hydroxy-benzo(a)pyrene glucuronidation in rat postmitochondrial supernatant in vitro in a dose-dependent manner. Piperine inhibition of these reactions in postmitochondrial supernatant from 3-methylcholanthrene- and phenobarbital-treated rats was similar to the controls. Inhibition by piperine of arylhydrocarbon hydroxylase (AHH) from 3-methylcholanthrene-treated rats was comparable to that observed with 7,8-benzoflavone. Piperine caused noncompetitive inhibition of hepatic microsomal AHH from the untreated and 3-methylcholanthrene-treated rats with a Ki of 30 microM which was close to the apparent Km of AHH observed in the controls. Similarly, the kinetics of inhibition of ethylmorphine-N-demethylase from control rat liver microsomes exhibited noncompetitive inhibition with an apparent Km of 0.8 mM and Ki of 35 microM. These studies demonstrated that piperine is a nonspecific inhibitor of drug metabolism which shows little discrimination between different cytochrome P-450 forms. Oral administration of piperine in rats strongly inhibited the hepatic AHH and UDP-glucuronyltransferase activities. The maximal inhibition of AHH observed within 1 hr restored to normal value in 6 hr. Pretreatment with piperine prolonged hexobarbital sleeping time and zoxazolamine paralysis time in mice at half the dose of SKF-525A. These results demonstrate that piperine is a potent inhibitor of drug metabolism.
PMID: 3917507 [PubMed - indexed for MEDLINE]
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This is an old paper, but not much has been done since 1985.
So now we have piperine (Bioperine) added to supplements to enhance their absorption. I just think it has to be used cautiously and by people who are NOT taking other drugs.
More here:
http://www.raysahelian.com/piperine.html
Posting on a board like this, one never knows who is reading what. So I cannot give a blanket recommendation for using Bioperine enhanced Curcumin.
I use the epic4health Curcugel 500 myself.
I also add curry spices to my soups, so I eat it too.
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Weezie looking at petunias 8.25.2017
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