Here's another quick reply that;s not very quick. I take mirapex for PD. It works well for my symptoms but I have gained 40 pounds. I also had major depression and took effexor which made my blood pressure go way up and caused a retinal occlusion. (I always had low BP) Now I'm on cymbalta among other drugs. Paula, you mentioned pamalor(nortrip). I was on pamalor for 10 years for migraines. It was a miracle drug for me. I never realized that people felt so good,until I started taking pamalor. I was able to get the dose down to 10mg/day and that is when my foot started with the tremor.4/05. I wonder if the pamalor held back the PD for a few years? Cheers! Fran