Thnx so much for all the info.....you are so right. exactly 3 hrs after dose, it wears off and the Dr also said to keep my dosage equal. I think you hit the nail on the head when you said taking more to help one set of muscles may overdose another....I think thats what was happening. I was taking more and more trying to get my legs to respond and my face didnt want to move more and more. So I think Im on track now with the mestinon and Im just going to hope the legs snap out of it soon.....dont think Ill try pred