I am not overly paranoid, but it breaks my heart pharmaceutical companies (they have bucks) have no interest in helping research that what will not benefit them. (ie - ongoing lifetime medication.) . When HyCy is done, it's done. I know it's not an option for me (PPMS does not indicate inflamation - that's why it is unresponsive to Interferons, etc) but it did help some RRs. Fampridine ($$$$$$$) has gotten FDA approval, a med. requiring monthly refills. OK, maybe I do feel a little paranoid and helpless. There's no incentive for big pharm. companies to find a stop to this madness.